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T15052 |
Dapansutrile
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NOD-like Receptor (NLR)
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NOD
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Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity. |
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T15050 |
Danicamtiv
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MYK-491,SAR 440181 |
Myosin
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Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. |
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T31640 |
Enrasentan
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SB-217242,SB 217242,SB217242 |
Endothelin Receptor
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Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial function. |
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TP2058L |
Catestatin acetate
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Catestatin acetate(142211-96-9 free base) |
Endogenous Metabolite
,
AChR
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Catestatin acetate is a non-competitive antagonist of nAChR and inhibits catecholamine release. Catestatin acetate regulates cardiac function and blood pressure. |
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T9232 |
Mitochondrial fusion promoter M1
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Mitochondrial Metabolism
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Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia... |
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T68037L |
CBS-1114 HCl
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N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base) |
Lipoxygenase
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CBS-1114 HCl (N-Phenylbenzamidrazone hydrochloride) is a 5-lipoxygenase inhibitor and an anti-inflammatory compound in a good eye-permeable model.CBS-1114 HCl maintains and improves cardiac function, attenuates cardiac d... |
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T14875 |
Indocyanine green
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Cardiogreen,IC Green,Foxgreen |
Others
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Indocyanine green (Cardiogreen) is a low toxicic fluorescent agent, is a tricarbocyanine dye,has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and fo... |
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TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
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Neuropeptide Y Receptor
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RFRP-1 (human) acetate is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduc... |
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T36569 |
KR-32568
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Sodium Channel
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KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated i... |
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T33451 |
ML 7
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ML7,ML-7 |
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ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury. |
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T70699 |
SAR296968
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SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure. |
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T75947 |
RFRP-1(human) TFA
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RFRP-1(human) TFA, an endogenous NPFF receptor agonist, exhibits potent activity with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. It significantly diminishes the contractile function of isolated rat and rabbi... |
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TP1937 |
RFRP-1(human)
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RFRP-1 (human) |
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Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume... |
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TP1827L |
Neuronostatin-13 human acetate
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Neuronostatin-13 human acetate(1096485-24-3 free base) |
Others
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Neuronostatin-13 human acetate is a 13-amino acid peptide hormone, which plays an important role in the regulation of hormonal and cardiac function. |
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T70280 |
KB-R7785
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KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect b... |
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T60377 |
CXL-1020
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CXL-1020, a nitroxyl (HNO) prodrug, enhances cardiac inotropy/lusitropy and Ca 2+ cycling in rats exhibiting abnormal relaxation, induces vasorelaxation, and augments cardiac function in canine models. It has been invest... |
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T39587 |
APJ receptor agonist 4
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APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models an... |
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T82778 |
Cardioexcitatory peptide 1
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Cardioexcitatory peptide 1, a potent neuropeptide derived from Achatina atria, exerts significant excitatory effects on cardiac function, additionally influencing the motility of muscular tissues and neural activities [1... |
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T35839 |
3-Iodothyronamine (hydrochloride)
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3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon... |
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TP1209 |
BNP (1-32), rat TFA (133448-20-1 free base)
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Brain Natriuretic Peptide (BNP) (1-32), rat TFA,BNP (1-32), rat TFA |
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Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeos... |
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T81837 |
MCaE12A
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MCaE12A, a potent modulator of RyR2, enhances the channel's sensitivity to cytoplasmic calcium concentrations, facilitating its opening. This compound serves as a critical instrument for examining RyR2 structure-to-funct... |
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T75878 |
Catestatin TFA
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Catestatin TFA, a 21-amino acid residue peptide, exhibits both cationic and hydrophobic properties. This endogenous peptide plays a crucial role in regulating cardiac function and blood pressure. It functions as a non-co... |
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TP2000 |
MM 07
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Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in... |
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T64266 |
KR-39038
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KR-39038 is an orally active GRK5 (G protein-coupled receptor kinase 5) inhibitor (IC50: 0.02 μM). KR-39038 inhibits the HDAC5 pathway in neonatal cardiomyocytes and significantly inhibits angiotensin II-induced hypertro... |
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T76044 |
Elabela(19-32) TFA
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Elabela(19-32) TFA, an effective fragment of ELABELA (ELA), selectively engages with the apelin receptor (APJ). This compound initiates G αi1 and β-arrestin-2 signaling, demonstrating EC50 values of 8.6 nM and 166 nM, re... |
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T68499 |
F15845 HBr
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F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotect... |
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T31657 |
Epothilone F
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Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F ... |
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T63153 |
APJ receptor agonist 5
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APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50:0.4 nM). APJ receptor agonist 5 has excellent pharmacokinetic profiles in rodent models of heart failure (HF) and an ... |
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T76223 |
NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
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Compound 39 (NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)) is a potent agonist of the APJ receptor, possessing a K i value of 0.6 nM. It is capable of activating Gαi1, with an EC 50 of 0.8 nM, and of recruiting β-arrestin2, with an E... |
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T82663 |
CU06-1004
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Sac-1004 |
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CU06-1004 (Sac-1004) is an orally active compound that acts as an endothelial dysfunction blocker. It mitigates endothelial dysfunction by inhibiting hyperpermeability and inflammation. The compound demonstrates efficacy... |
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T65994 |
(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
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Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ... |
